Anti-LMNA Monoclonal Antibody

品牌：solarbio | 货号：K000142M

宿主	Mouse
英文名称	Anti-LMNA Monoclonal Antibody
别名	CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;Lamin A/C
应用	WB
稀释比例	WB 1:1000.
蛋白分子量	74/65/71/64/63/69kDa
Gene ID	4000
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2a
免疫原	Purified recombinant human LMNA protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human LMNA protein fragments expressed in E.coli.
Subcellular Locations	Nucleus Nucleus envelope Nucleus lamina Nucleus speckle nucleoplasm
Swiss Prot	P02545
克隆号	3D6-F4-B7
克隆类型	Monoclonal Antibody
背景资料	The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.