
Anti-LMNA 单克隆抗体
产品名称: Anti-LMNA 单克隆抗体
英文名称: Anti-Lamin A/C Monoclonal Antibody
产品编号: K000143M
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: 2025-03-05T10:41:20
使用范围: WB IF
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
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Anti-LMNA Monoclonal Antibody
品牌:solarbio | 货号:K000143M
宿主 Mouse 英文名称 Anti-LMNA Monoclonal Antibody 别名 CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LDP1;LFP;LGMD1B;LMN1;LMNC;LMNL1;MADA;PRO1;Lamin A/C 应用 WB IF 稀释比例 WB 1:1000. ICC 1:200. 交叉反应 Human 蛋白分子量 74/65/71/64/63/69kDa Gene ID 4000 保存 Store at -20°C. Avoid freeze / thaw cycles. 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 纯化方法 Affinity purification 亚型 IgG1 免疫原 Purified recombinant human LMNA protein fragments expressed in E.coli. 性状 液体 Public Immunogen Range Purified recombinant human LMNA protein fragments expressed in E.coli. Subcellular Locations Nucleus Nucleus envelope Nucleus lamina Nucleus speckle nucleoplasm Swiss Prot P02545 克隆号 5D12-C6-E9 克隆类型 Monoclonal Antibody 背景资料 The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.